Techniques for the diagnosis of invasive fungal infection, including antigen testing, nucleic acid detection and radiological imaging,
have improved greatly in recent years. They have the potential to impact on patient management through replacing empirical antifungal
strategies with targeted and pre-emptive therapy.
Significant advances in early diagnosis, most notably through the application of non-invasive techniques including antigen testing, nucleic acid detection and radiological detection of fungal infection, have the potential to
impact on empirical strategies. When incorporated into care pathways, these techniques may be used to guide pre-emptive therapy and reduce unnecessary empirical antifungal use. Benefits from this approach include not only reduced drug acquisition
costs but also reduced morbidity and mortality from drug-related adverse events and decreased hospital length of stay. The ultimate goal will be a reduction in fungal-related death and improved
overall survival.
J. Antimicrob. Chemother.(2008) 61 (suppl 1): 3-6.
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